Xentry-Gap19 inhibits Connexin43 hemichannel opening especially during hypoxic injury
نویسندگان
چکیده
منابع مشابه
Connexin43 Hemichannel-Mediated Regulation of Connexin43
BACKGROUND Many signaling molecules and pathways that regulate gap junctions (GJs) protein expression and function are, in fact, also controlled by GJs. We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs. Using a cell culture model in which nonjunctional connexin43 (Cx43) hemichannels were activated by cadmium (Cd(2+)), we tested this hypothesis. PRINCIPA...
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Connexin hemichannels have been proposed as a diffusion pathway for the release of extracellular messengers like ATP and others, based on connexin expression models and inhibition by gap junction blockers. Hemichannels are opened by various experimental stimuli, but the physiological intracellular triggers are currently not known. We investigated the hypothesis that an increase of cytoplasmic c...
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ژورنال
عنوان ژورنال: Drug Delivery and Translational Research
سال: 2020
ISSN: 2190-393X,2190-3948
DOI: 10.1007/s13346-020-00763-y